Through the use of magnetic resonance imaging (MRI), we aim to better understand congitive aging and impairment. We obtain brain images from a subsample of 200 respondents.
Each individual going through MRI testing will receive numerous structural and functional MRI scans, according to the recently developed Laboratory of Neuro Imaging (LONI) Alzheimer's Disease Neuroimaging Initiative (ADNI) 3 protocol. Scan sequences such as T1, T2*, DTI, and FLAIR allow us to better comprehend the presentation and physical development of MCI and dementia, while resting state fMRI will be used to help decipher functional differences that develop as these individuals begin to lose cognitive functionality.
Structural and functional images will be collected and compared with the other areas of our study including genetics, cognitive and behavioral testing, and blood biomarkers. Ultimately, our goal is to first obtain a rich data set that details the initiation and progression of mild cognitive impairment and dementia. Afterwards, our aim is better correlate the presentation and progression of the disease with the other areas of the project to give us a better understanding as to how structural and functional data aligns with behavioral and cognitive deficits.